We’re working hard to raise money to fund mental illness research.

Medical research provides a massive step forward in the search to find a cure for mental illness. Awareness is important, but it is not enough. We need direct and meaningful action if we are going to find a cure. Unfortunately research into mental health is desperately underfunded, so we are working hard to raise money and close the funding gap. Medical knowledge about mental illness is where asthma, cancer, diabetes and most other chronic illnesses were 60 years ago.

Professor Brian Dean
Head Biological Psychiatry & Mental Health

Dr Andrea Gogos, Researcher
Biological Psychiatry & Mental Health 

ONE IN FIVE'S supported research project

Currently ONE IN FIVE is funding research at the Florey Institute of Neuroscience and Mental Health.

The work of the Florey’s Biological Psychiatry & Mental Health Division aims to understand the cause of schizophrenia, bipolar disorder and major depression and the mechanism of action of drugs used to treat these disorders. The ultimate goal of such research is to provide a foundation for drug design for the disorders.

We expect that drugs aimed at targets involved in causing schizophrenia, bipolar disorder and major depression would dramatically improve the well-being of people, while producing a minimum number of side-effects.


We are working to understand the role of inflammatory pathways in the brains of people with the disorder to discover how they may cause the illness.

Depression and suicide

We have extensive gene expression data on the brains of people with depression and those who have died by suicide. The data tells us which pathways in the brain are involved in causing depression and the drive to suicide. At present we do not have funding to get a better understanding of how these pathways actually can make people depressed or drive them to suicide.

Schizophrenia and psychotic disorders

We are working with Vanderbilt University to characterise the potency of their new muscarinic receptor drugs in our human brain tissue and whether they work well in the brains of people with schizophrenia. The family of drugs we are working on are about to go into clinical trials and may become an exciting new treatment for the disorder. Current data suggest they will act to alleviate cognitive deficits and psychotic symptoms.

We need your help to continue our important work and improve the lives of Australians who suffer from mental illness. 


Where does the money go

  • $20 pays to process analyse tissue in experiments performed to understand the causes of mental illness.
  • $40 can provide 1 hour of a research assistant's laboratory time, speeding our progress towards results.
  • $50 pays for specialised substances like molecular dyes vital for completing experiments.
  • $100 is enough to provide laboratory plastic ware to test a potential new treatment for mental illness.
  • $500 is enough to provide new laboratory equipment for genetic experiments requiring ultra clean conditions.

You can make a difference, donate to ONE IN FIVE today.