The importance of gender differences in aetiology, diagnoses and treatment has traditionally been neglected in psychiatry. The Women’s Mental Health Division recognises the complex interaction of biological, psychological and social factors that give rise to clear differences in men and women, and aims to provide gender-tailored novel treatments and interventions. Principle areas of focus included clinical trials to assess novel treatments in borderline personality disorder, schizophrenia, and perimenopause. Expanding current scientific knowledge on the role of the neuroendocrine system in mental illness is critical to these projects. Exploratory studies includ exploring potential hormonal and medication treatments for men and women with borderline personality disorder and schizophrenia. NRAMP, the National Register of Antipsychotic Medication in Pregnancy, is the world’s first registry of its kind. The database aims to develop our understanding of the effects of antipsychotic medications taken during pregnancy and the post-natal period. Alongside research, the team is in a unique position, sitting adjunct to the Women’s Mental Health Clinic. This provides an interface of research and clinical practice, ensuring direct translation of the treatments and interventions, developed to ensure real world change.